{"id":90,"date":"2021-07-06T18:55:55","date_gmt":"2021-07-06T18:55:55","guid":{"rendered":"http:\/\/10.250.7.211\/?page_id=90"},"modified":"2025-04-18T08:01:50","modified_gmt":"2025-04-18T08:01:50","slug":"research","status":"publish","type":"page","link":"https:\/\/mgbio.asab.nust.edu.pk\/index.php\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"90\" class=\"elementor elementor-90\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-16b5831 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"16b5831\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-966fb80\" data-id=\"966fb80\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b4140c2 elementor-widget elementor-widget-heading\" data-id=\"b4140c2\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Research Areas<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ee01a46 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"ee01a46\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-aefb4bf elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"aefb4bf\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ec3ea96\" data-id=\"ec3ea96\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-62d52ce elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"62d52ce\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-dot-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Microbial Genomics & Bioinformatics<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-dot-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Systems & Network Biology<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-dot-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Whole Genome Sequencing, Assembly and Annoation<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-dot-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Genomic Epidemiology and Antimicrobial Resistance<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-dot-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Pangenome-Reverse Vaccinology (Pan-RV)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a71ed48 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a71ed48\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cf10e9d\" data-id=\"cf10e9d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3e972ca elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"3e972ca\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-def2565 elementor-widget elementor-widget-elementskit-accordion\" data-id=\"def2565\" data-element_type=\"widget\" data-widget_type=\"elementskit-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" >\n        <div class=\"elementskit-accordion floating-style\" id=\"accordion-6a0c7ee8a4049\">\n\n            \n                <div class=\"elementskit-card active\">\n                    <div class=\"elementskit-card-header\" id=\"primaryHeading-0-def2565\">\n                        <a href=\"#collapse-0c1852b6a0c7ee8a4049\" class=\"ekit-accordion--toggler elementskit-btn-link collapsed\" data-ekit-toggle=\"collapse\" data-target=\"#Collapse-0c1852b6a0c7ee8a4049\" aria-expanded=\"true\" aria-controls=\"Collapse-0c1852b6a0c7ee8a4049\">\n                            \n                            <span class=\"ekit-accordion-title\">Microbial Genomics &amp; Bioinformatics<\/span>\n\n                            \n                                <div class=\"ekit_accordion_icon_group\">\n                                    <div class=\"ekit_accordion_normal_icon\">\n                                        <!-- Normal Icon -->\n\t\t\t\t\t\t\t\t\t\t<i class=\"icon icon-down-arrow1\"><\/i>                                    <\/div>\n\n                                    <div class=\"ekit_accordion_active_icon\">\n                                        <!-- Active Icon -->\n\t\t\t\t\t\t\t\t\t\t<i class=\"icon icon-up-arrow\"><\/i>                                    <\/div>\n                                <\/div>\n\n                            \n                                                    <\/a>\n                    <\/div>\n\n                    <div id=\"Collapse-0c1852b6a0c7ee8a4049\" class=\" show collapse\" aria-labelledby=\"primaryHeading-0-def2565\" data-parent=\"#accordion-6a0c7ee8a4049\">\n\n                        <div class=\"elementskit-card-body ekit-accordion--content\">\n                            We are microbial- genomics and bioinformatics research (MGB) group interested in genomic epidemiology and comparative genomics to study the evolution and transmission of bacterial pathogens. We are particularly interested in the regional crisis of growing antimicrobial resistance and dissemination of multidrug resistant pathogens, also like to develop of tools, databases for pathogen genome analysis, prospective surveillance and tracking of emerging pathogens in the environment and clinical settings using whole genome sequencing and bioinformatics analysis. We are using comparative pangenome analysis and phylogenetics approaches to study the genome evolution, transmission, and resistance patterns in bacterial pathogens such as staphylococcus, pseudomonas, Klebsiella and Acinetobacter etc. We have developed high-throughput screening Tools\/Software capable to analyses of microbial pangenome (big data) and therapeutic candidates\u2019 identification. Our tools include:\n<table>\n<tbody>\n<tr>\n<td style=\"padding: 10px\"><a class=\"lab-tool-btn\" style=\"padding: 10px 12px;background: #003380;color: white;text-align: center;text-decoration: none;font-weight: 500;border-radius: 4px;font-size: 14px\" href=\"https:\/\/sourceforge.net\/projects\/vacsol\/\">\nVacSol<span style=\"font-size: 0.7em;vertical-align: super\">\u24b8<\/span>\n<\/a><\/td>\n<td style=\"padding: 10px\"><a class=\"lab-tool-btn\" style=\"padding: 10px 12px;background: #003380;color: white;text-align: center;text-decoration: none;font-weight: 500;border-radius: 4px;font-size: 14px\" href=\"https:\/\/sourceforge.net\/projects\/panrv2\/\">\nPanRV<span style=\"font-size: 0.7em;vertical-align: super\">\u24b8<\/span>\n<\/a><\/td>\n<td style=\"padding: 10px\"><a class=\"lab-tool-btn\" style=\"padding: 10px 12px;background: #003380;color: white;text-align: center;text-decoration: none;font-weight: 500;border-radius: 4px;font-size: 14px\" href=\"https:\/\/abampdb.mgbio.tech\/\">\nAbAMPdb<span style=\"font-size: 0.7em;vertical-align: super\">\u24b8<\/span>\n<\/a><\/td>\n<td style=\"padding: 10px\"><a class=\"lab-tool-btn\" style=\"padding: 10px 12px;background: #003380;color: white;text-align: center;text-decoration: none;font-weight: 500;border-radius: 4px;font-size: 14px\" href=\"https:\/\/nustedupk0-my.sharepoint.com\/...\">\nB-vac<span style=\"font-size: 0.7em;vertical-align: super\">\u24b8<\/span>\n<\/a><\/td>\n<td style=\"padding: 10px\"><a class=\"lab-tool-btn\" style=\"padding: 10px 12px;background: #003380;color: white;text-align: center;text-decoration: none;font-weight: 500;border-radius: 4px;font-size: 14px\" href=\"https:\/\/nustedupk0-my.sharepoint.com\/...\">\nB-pan<span style=\"font-size: 0.7em;vertical-align: super\">\u24b8<\/span>\n<\/a><\/td>\n<td style=\"padding: 10px\"><a class=\"lab-tool-btn\" style=\"padding: 10px 12px;background: #003380;color: white;text-align: center;text-decoration: none;font-weight: 500;border-radius: 4px;font-size: 14px\" href=\"http:\/\/vaccinesai.mgbio.tech\/\">\nVacSol-ML(ESKAPE)<span style=\"font-size: 0.7em;vertical-align: super\">\u24b8<\/span>\n<\/a><\/td>\n<td style=\"padding: 10px\"><a class=\"lab-tool-btn\" style=\"padding: 10px 12px;background: #003380;color: white;text-align: center;text-decoration: none;font-weight: 500;border-radius: 4px;font-size: 14px\" href=\"http:\/\/vaccinesai.mgbio.tech\/\">\nB-vac AI<span style=\"font-size: 0.7em;vertical-align: super\">\u24b8<\/span>\n<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nIn the Structural Bioinformatics domain, we are employing the Homology structural modeling,\u00a0<i>Ab-initio\u00a0<\/i>modeling, Protein-protein interaction studies, Protein-Ligand interaction studies, Protein-nucleotide studies, Pharmacophore modeling, structural visualization of protein by using different tools                        <\/div>\n\n                    <\/div>\n\n                <\/div><!-- .elementskit-card END -->\n\n                \n                <div class=\"elementskit-card active\">\n                    <div class=\"elementskit-card-header\" id=\"primaryHeading-1-def2565\">\n                        <a href=\"#collapse-54408196a0c7ee8a4049\" class=\"ekit-accordion--toggler elementskit-btn-link collapsed\" data-ekit-toggle=\"collapse\" data-target=\"#Collapse-54408196a0c7ee8a4049\" aria-expanded=\"true\" aria-controls=\"Collapse-54408196a0c7ee8a4049\">\n                            \n                            <span class=\"ekit-accordion-title\">Systems &amp; Network Biology<\/span>\n\n                            \n                                <div class=\"ekit_accordion_icon_group\">\n                                    <div class=\"ekit_accordion_normal_icon\">\n                                        <!-- Normal Icon -->\n\t\t\t\t\t\t\t\t\t\t<i class=\"icon icon-down-arrow1\"><\/i>                                    <\/div>\n\n                                    <div class=\"ekit_accordion_active_icon\">\n                                        <!-- Active Icon -->\n\t\t\t\t\t\t\t\t\t\t<i class=\"icon icon-up-arrow\"><\/i>                                    <\/div>\n                                <\/div>\n\n                            \n                                                    <\/a>\n                    <\/div>\n\n                    <div id=\"Collapse-54408196a0c7ee8a4049\" class=\" show collapse\" aria-labelledby=\"primaryHeading-1-def2565\" data-parent=\"#accordion-6a0c7ee8a4049\">\n\n                        <div class=\"elementskit-card-body ekit-accordion--content\">\n                            <p>We are also interested in system-level analysis and tools for studying the complex biological systems and processes such as diseases and pathways, Together with collaborators we are constructing and analyses the Biological Regulatory Networks (BRNs) and Models through formal modeling approaches. Through these model simulation we try to understand the behavior of an entire biological system (holistic) and relationships between its components (individual entities) and identification markers (states\/paths\/trajectories) involved in genomic variation and their association with processes\/ diseases, identification of therapeutic targets in these pathways.\u00a0<\/p>                        <\/div>\n\n                    <\/div>\n\n                <\/div><!-- .elementskit-card END -->\n\n                                        <\/div>\n    <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Areas Microbial Genomics &#038; Bioinformatics Systems &#038; Network Biology Whole Genome Sequencing, Assembly and Annoation Genomic Epidemiology and Antimicrobial [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_theme","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-90","page","type-page","status-publish","hentry"],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":"Amjad Ali","author_link":"https:\/\/mgbio.asab.nust.edu.pk\/index.php\/author\/mgbioinfo\/"},"rttpg_comment":0,"rttpg_category":null,"rttpg_excerpt":"Research Areas Microbial Genomics &#038; Bioinformatics Systems &#038; Network Biology Whole Genome Sequencing, Assembly and Annoation Genomic Epidemiology and Antimicrobial [&hellip;]","_links":{"self":[{"href":"https:\/\/mgbio.asab.nust.edu.pk\/index.php\/wp-json\/wp\/v2\/pages\/90","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mgbio.asab.nust.edu.pk\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mgbio.asab.nust.edu.pk\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mgbio.asab.nust.edu.pk\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mgbio.asab.nust.edu.pk\/index.php\/wp-json\/wp\/v2\/comments?post=90"}],"version-history":[{"count":147,"href":"https:\/\/mgbio.asab.nust.edu.pk\/index.php\/wp-json\/wp\/v2\/pages\/90\/revisions"}],"predecessor-version":[{"id":3734,"href":"https:\/\/mgbio.asab.nust.edu.pk\/index.php\/wp-json\/wp\/v2\/pages\/90\/revisions\/3734"}],"wp:attachment":[{"href":"https:\/\/mgbio.asab.nust.edu.pk\/index.php\/wp-json\/wp\/v2\/media?parent=90"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}